top of page
acr_edited.jpg

Acridine/Lewis Acid Complexes as Powerful Photocatalysts: A Combined Experimental and Mechanistic Study

Dillon R. L. Rickertsen, Joshua D. Crow, Tamal Das, Ion Ghiviriga, Jennifer S. Hirschi*, Daniel Seidel*

​

ACS Catalysis 2024, 14, 19, 14574–14585

Resolving Conflicting Mechanisms for Photoredox Allylic sp3‑CHArylation Using Deuterium-Labeling and Isotope Effects

Anuradha Dagar, Tamal Das, Sharath C. Mallojjala, Jennifer S. Hirschi* and Mathew J. Vetticatt*

​

ACS Catalysis 14, 2024, 9469-9475

Transition State Analysis of Key Steps in Dual Photoredox-Cobalt-Catalyzed Elimination of Alkyl Bromides

Victor O. Nyagilo, Sharath C. Mallojjala and Jennifer S. Hirschi*​​​​

​​

ACS Catalysis 2024, 14, 7, 4683-4689

Altering the Localization of an Unpaired Spin in a Formal Ni(V) Species

Ayushi Awasthi, Sharath C. Mallojjala, Rakesh Kumar, Raju Eerlapally, Jennifer S. Hirschi,* and Apparao Draksharapu*

​

Chem. Eur. J., 30, 2024

Chiral Quaternary Ammonium Salt-Catalyzed Enantioselective Addition Reactions of Hydantoins

Katharina Röser, Lucas Prameshuber, Sajid Jahangir,  Sharath Chandra Mallojjala, Jennifer S. Hirschi,* and Mario Waser*

​

Helv. Chim. Acta, 107, 2024,

An Arm-to-Disarm Strategy to Overcome Phenotypic AMR in Mycobacterium tuberculosis

Anand Kumar, Shalini Birua, Sharath S. Mallojjala, Piyali Mukherjee, Abdul Akhir, Jennifer Hirschi,* and Harinath Chakrapani*​​

​

​​                               BioRxiv

Copper-Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes

Brian S Daniel, Xintong Hou, Stephanie A Corio, Lindsey M Weissman, Vy M Dong*, Jennifer S Hirschi*, Shaozhen Nie*

​

Anger. Chem. Int. Ed  2023, 62, 1-9

Stereospecific Nickel-Catalyzed Cross-Electrophile Coupling Reaction of Alkyl Mesylates and Allylic Difluorides to Access Enantioenriched Vinyl Fluoride-Substituted Cyclopropanes

Patricia C. Lin, Chetan Joshi, Tristan M. McGinnis, Sharath Chandra Mallojjala, Amberly B. Sanford, Jennifer S. Hirschi*, and Elizabeth R. Jarvo*


ACS Catalysis  2023, 13, 7, 4488-4499

Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging

Amanda K. East, Michael C. Lee, Lukas P. Smaga, Chang Jiang, Sharath C. Mallojjala, Jennifer S. Hirschi, and Jefferson Chan*


Organic Letters  2022, 24, 46, 8509-8513

NitreneResize.png
hydrofx.png
RemoteStereocontrol.png

Enzymatic Nitrogen Insertion into Unactivated C–H Bonds

Soumitra V. Athavale*, Shilong Gao, Anuvab Das, Sharath Chandra Mallojjala, Edwin Alfonzo, Yueming Long, Jennifer S. Hirschi*, and Frances H. Arnold*


Journal of the American Chemical Society  2022, 144, 41, 19097-19105

Probing the Free Energy Landscape of Organophotoredox-Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes

Sharath Chandra Mallojjala, Victor O. Nyagilo, Stephanie A. Corio, Alafate Adili, Anuradha Dagar, Kimberly A. Loyer, Daniel Seidel*, and Jennifer S. Hirschi*


Journal of the American Chemical Society  2022, 144, 38, 17692-17699

Mechanism and Origin of Remote Stereocontrol in the Organocatalytic Enantioselective Formal C(sp2)–H Alkylation Using Nitroalkanes as Alkylating Agents

Sharath Chandra Mallojjala, Rahul Sarkar, Rachael W. Karugu, Madhu Sudan Manna, Sayan Ray, Santanu Mukherjee*, and Jennifer S. Hirschi*


Journal of the American Chemical Society  2022, 144, 38, 17399-17406

PUBLICATIONS

References and Links to Papers

Screen Shot 2022-03-23 at 5.31_edited.jpg
Screen Shot 2022-01-14 at 6.33.10 PM.png
Screen Shot 2022-01-14 at 6.42.43 PM.png

Isotope Effects Reveal the Catalytic Mechanism of the Archetypical Suzuki-Miyaura Reaction

Joshi, C., Macharia, J., Izzo, J., Wambua, V., Kim, S., Hirschi, J., Vetticatt, M.

​

ACS Catal. 2022, 12, 5, 2959–2966

Probing Catalyst Function- Electronic Modulation of Chiral Polyborate Anionic Catalysts

Osminski, W., Lu, Z., Zhao, W., Mohammadlou, A., Yin, X., Matthews, E., Canestraight, V., Staples, R., Allen, C., Hirschi, J. and Wulff.

​

J. Org. Chem. 2021, 86, 24, 17762–17773

Biocatalytic, Intermolecular C−H Bond Functionalization for the Synthesis of Enantioenriched Amides

Athavale, S.; Gao, S.; Liu, Z.; Mallojjala, S.; Hirschi, J.; Arnold, F.

​

Angewandte Chemie 2021, 133 (47), 25068-25073

A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing

Gardner, S.; Brady, C.; Keeton, C.; Yadav, A.; Mallojjala, S.; Lucero, M.; Su, S.; Yu, Z.; Hirschi, J.; Mirica, L.; Chan, J.

Angewandte Chemie 2021, 133 (34), 19008-19014.

Rapid Evaluation of the Mechanism of Buchwald–Hartwig Amination and Aldol Reactions Using Intramolecular 13C Kinetic Isotope Effects

Wambua, V., Hirschi, J., Vetticatt, M.

ACS Catal. 2021, 11, 1, 60–67

A Selenourea-Thiourea Brønsted Acid Catalyst Facilitates Asymmetric Conjugate Additions of Amines to α,β-Unsaturated Esters

Lin, Y.; Hirschi, W. J.; Kunadia, A.; Paul, A.; Ghiviriga, I.; Ab-boud, K. A.; Karugu, R. W.; Vetticatt, M. J.; Hirschi, J.S.; Seidel, D

J. Am. Chem. Soc. 2020, 142, 12, 5627–5635

Boosting NAD(+) with a small molecule that activates NAMPT

Gardell, S. J.; Hopf, M.; Khan, A.; Dispagna, M.; Sessions, E. H.; Falter, R.; Kapoor, N.; Brooks, J.; Culver, J.; Petucci, C.; Ma, C-T.; Cohen, S. E.; Tanaka, J.; Burgos, E. S.; Hirschi, J. S.; Smith, S. R.; Sergienko, E.; Pinkerton, A. B.

Nature. Comm. 2019, 10, 3241.

Transition state analysis of an enantioselective Michael addition by a bifunctional thiourea organocatalyst

Izzo, J. A.; Myshchuk, Y; Hirschi, J. S.*; Vetticatt, M. J.

Org. Biomol. Chem 2019, 17, 3934-3939.

Allosteric Activation Shifts the Rate-Limiting Step in a Short-Form ATP Phosphoribosyltransferase

Fisher, G.;  Thomson,C. M.; Stroek, R.; Czekster, C. M.; Hirschi, J. S.; da Silva, R. G.

Biochemistry. 2018, 57, 4357-4367.

C-13 Kinetic Isotope Effects as a Quantitative Probe to Distinguish Between Enol and Enamine Mechanisms in Aminocatalysis

Roytman, V. A.; Karugu, R. W.; Hong, Y.; Hirschi, J.; Vetticatt, M.
Chem. Eur. J. 2018, 24, 8098-8102

Asymmetric Induction via a Helically Chiral Anion: Enantioselective Pentacarboxycyclopentadiene Bronsted Acid-Catalyzed Inverse-Electron-Demand Diels-Alder Cycloaddition of Oxocarbenium Ions

Gheewala, C.D.; Hirschi, J. S.; Lee, W-H.; Paley, D. W.; Vetticatt, M. J.;  Lambert, T. H.  
J. Am. Chem. Soc. 2018, 140, 3523-3527

Formation of hydrazones and stabilized boron-nitrogen heterocycles in aqueous solution from carbohydrazides and ortho-formylphenylboronic acids

Gu, H.; Chio, T. I.; Lei, Z.; Staples, R. J.; Hirschi, J. S.; Bane, S.
Org. Biomol. Chem. 2017, 15, 7543-7548.

A Designed Approach to Enantiodivergent Enamine Catalysis

Macharia J.; Victor, W.; Hong, Y.; Harris, L.; Hirschi, J. S.; Evans, G. B.; Vetticatt, M. J.
Angew. Chem. Int. Ed. 2017, 56, 8756-8760.

Catalytic Enantioselective Synthesis of Lactams through Formal [4+2] Cycloaddition of Imines with Homophthalic Anhydride

Jarvis, C. L.; Hirschi, J. S.; Vetticatt, M. J.; Seidel, D.
Angew. Chem. Int. Ed. 2017, 56, 2670-2674.

Isotope Effects Reveal the Mechanism of Enamine Formation in L-Proline-Catalyzed alpha-Amination of Aldehydes

Ashley, M. A.; Hirschi, J. S.; Izzo, J. A.; Vetticatt, M. J.
J. Am. Chem. Soc. 2016, 138, 1756-1759.

PRIOR TO BINGHAMTON UNIVERSITY

Transition States of Native and Drug-Resistant HIV-1 Protease are the Same

Kipp, D. R.; Hirschi, J. S.; Wakata, A.; Goldstein, H.; Schramm, V. L.
Proc. Natl. Acad. Sci., 2012, 109, 6543–6548.

Arsenate and Phosphate as Nucleophiles at the Transition States of Human Purine Nucleoside Phosphorylase

Silva, R. G.; Hirschi, J. S.; Ghanem, M.; Murkin, A.; Schramm, V. L.
Biochemistry, 2011, 50, 2701–2709.

Conformational Dynamics in Human Purine Nucleoside Phosphorylase with Reactants and Transition-State Analogues

Hirschi, J. S.; Arora, K.; Brooks, C. L. III; Schramm, V. L.  
J. Phys. Chem. B, 2010, 114, 16263–16272.

Newtonian Kinetic Isotope Effects. Observation, Prediction, and Origin of Heavy-Atom Dynamic Isotope Effects

Kelly, K. K.; Hirschi, J. S.; Singleton, D. A.  
J. Am. Chem. Soc. 2009, 131, 8382–8383.

Transition-State Geometry Measurements from C-13 Isotope Effects. The Experimental Transition State for the Epoxidation of Alkenes with Oxaziridines

Hirschi, J. S.; Tetsuya, T.; Hang, C.; Singleton, D. A.  
J. Am. Chem. Soc. 2009, 131, 2397–2403.

Recrossing and Dynamic Matching Effects on Selectivity in a Diels-Alder Reaction

Wang, Z; Hirschi, J.S.; Singleton, D.A.  
Angew. Chem. Int. Ed. 2009, 48, 9156–9159.

Phenomenon of optical self-purification of chiral non-racemic compounds

Soloshonok, V. A.; Ueki, H.; Yasumoto, M.; Mekala, S.; Hirschi, J. S.; Singleton, D. A.
J. Am. Chem. Soc. 2007, 129, 12112–12113.

Insights into the mechanism of flavoprotein-catalyzed amine oxidation from nitrogen isotope effects on the reaction of N-methyltryptophan oxidase

Ralph, E. C.; Hirschi, J. S.; Anderson, M. A.; Singleton, D. A.; Cleland, W. W.; Fitzpatrick, P.F.
Biochemistry 2007, 46, 7655–7664.

The Normal Range for Secondary Swain-Schaad Exponents Without Tunneling or Kinetic Complexity

Hirschi, J. S.; Singleton, D. A.  
J. Am. Chem. Soc. 2005, 127, 3294–3295.

Asymmetric Dihydroxylation of Allenes

Fleming, S. A.; Carroll, S. M.; Hirschi, J. S.; Renmao, L.; Pace, J. L.; Redd, J. T.  
Tet. Lett. 2004, 45, 3341–3343.

Exo-selective Diels-Alder Reactions of Vinylazepines. Origin of Divergent Stereoselectivity in Diels-Alder Reactions of Vinylazepines, Vinylpiperideines, and Vinylcycloalkenes

Boren, B.; Hirschi, J. S.; Reibenspies, J. H.; Tallant, M. D.; Singleton, D. A.; Sulikowski, G. A.  
J. Org. Chem. 2003, 68, 8991–8995

©2020 by Hirschi Lab

bottom of page